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KMID : 1137820160370010046
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의공학회지
2016 Volume.37 No. 1 p.46 ~ p.52
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Improved Manufacturing Method of Discoidal Nanoparticles for Cancer Theranostics
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Bae Jang-Yeol
Oh Eun-Seol
Lee Hyun
Key Jae-Hong
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Abstract
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Nanoparticles have been studied as therapeutic and imaging agents for the early detection and cure of cancer, Cancer Theranostics. Nanoparticles were considered to effectively target cancer cells due to Enhanced Permeability and Retention (EPR) effect and most nanoparticles have been evaluated by using spherical shapes. However, the problem that the EPR effect is not so effective for human cancer therapy was recently brought up. Therefore, in this study, we suggest novel discoidal nanoparticles to overcome this problem, focusing on their manufacturing process and quality control. Herein, we demonstrate the improved manufacturing method of discoidal nanoparticles and their potential to apply to MCF 7, human breast cancer treatment.
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KEYWORD
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discoidal nanoparticles, shape, cancer, drug delivery, imaging
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